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DSIP crosses the blood-brain barrier through a saturable transport system, confirming it is actively transported into the brain rather than passively diffusing across

Given the known pleiotropy of ETC inhibition (for example, AMPK activation and ATP depletion), these approaches will probably require context-aware deployment rather than broad application

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Absorption issues: Some medical conditions such as pernicious anemia, celiac disease, Crohn's disease, and surgical removal of part of the stomach or intestines can impair the body's ability to absorb B12 from food